Tontonoz Lab Journal Club

The Tontonoz Lab administers a monthly “Molecular Metabolism” journal club dedicated to discussing cutting edge discoveries that impact metabolic research. 

Our group includes members of the following professors’ laboratories: Dr. Peter Tontonoz, Dr. Stephen Young, Dr. Jake Lusis, Dr. Andrea Hevener, Dr. Steven Bensinger, Dr. Elizabeth Tarling, Dr. Thomas Vallim, Dr. Stephanie Correa, Dr. Tamer Sallam, Marc Liesa-Roig

We meet on the third Monday of each month at 1pm. If you would like to join our mailing list, please send a request to Ingrid Gonzalez, or join our Google group

journal cover nature medicine march 2018
journa cover cell metabolism may 2007
journal cover cell metabolism july 2013
journal cover cell metabolism dec 1995
journal cover molecular and cellular biology sep 2015
journal cover molecular endocrinology dec 2008

Papers Presented from October 16, 2015 Onward

Date Presenter Lab Journal Citation
6/27/2022 Maykel Rodriguez Lab Nature ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids
5/16/2022 Alexander Nguyen Tontonoz Lab Nature Regulation of liver subcellular architecture controls metabolic homeostasis
4/18/2022 Liujuan Cui Tontonoz Lab Science Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP – dependent IL – 1 production
3/21/2022 Rohith Nagari Tontonoz Lab Nature Low-dose metformin targets the lysosomal AMPK
pathway through PEN2
8/16/21 Rozeta Avetisyan Reue Lab JCI Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice
7/19/21 Dr. Irina Lapina Sallam Lab Cell Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
6/21/21 Dr. Kelsey Jarrett Tarling/Vallim Lab Cell Metabolism TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis
5/17/21 Vincent Gutierrez Liesa Lab Nature Metabolism Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity
4/19/21 Tim Moore Lusis Lab Cell Metabolism Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health
3/15/21 Kelly Kennewick Bensinger Lab Nature Lipid signalling enforces functional specialization of Treg cells in tumours
2/22/21 Lauren Uchiyama Tontonoz Lab Cell NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
1/25/21 Mirian Krystel De Siqueira Villanueva Lab Cell Metabolism Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus
11/16/20 Vincent Gutierrez Liesa Lab Science Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
10/19/20 Arthe Raajendiran Villanueva Lab Cell Metabolism Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain
9/21/20 Dr. Karthickeyan Chella Krishnan Lusis Lab Cell Metabolism "Serine Catabolism Feeds NADH when Respiration Is Impaired". He also wanted to share the preview for this article and the supplemental figures.
8/17/20 Alex Bedard Tontonoz Lab Cell CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
7/20/20 Dr. Zhenqi Zhou Hevener Lab Nature Treatment of type 2 diabetes with the designer cytokine IC7Fc
6/15/20 Dr. Dan Wang Sallam Lab Cell Identification of ALK in Thinness
5/18/20 Dr. Kelsey Jarrett Tarling/Vallim Lab Molecular Metabolism Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity
5/4/20 Min Sub and Ian Ford Bensinger Lab Nature The gluconeogenic enzyme PCK1phosphorylates INSIG1/2 for lipogenesis
4/20/20 Dr. Megan Massa Correa Lab Cell Metabolism Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding
4/6/20 Dr. Yajing Gao Tontonoz Lab Nature Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate
3/16/20 Dr. Zhenqi Zhou Hevener Lab CANCELLED DUE COVID-19 OUTBREAK
2/24/20 Dr. Carrie Wiese Reue Lab Cell Metabolism TAZ Is a Negative Regulator of PPARg Activity inAdipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance
1/20/20 Dr. Yuta Shimanaka Tontonoz Lab Cell Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis
11/18/19 Dr. Xu Xiao Tontonoz Lab Cell Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
10/21/19 Dr. Irina Lapina Sallam Lab Cell Metabolism Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae
9/16/19 Dr. Michael Shum Liesa Lab Cell Metabolism Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
8/19/19 Dr. John Kennelly Tontonoz Lab Nature SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
7/15/19 Dr. Hayato Muranaka Bensinger Lab Nature Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
6/17/19 Dr. Karthickeyan Krishnan Lusis Lab Cell Metabolism A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
5/20/19 Dr. Leslie Sedgeman Tarling/Vallim Lab Cell Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression
Supplement: 2019-05 Hancock et al Cell (from our google drive)
4/15/19 Dr. Ed Van Veen Correa Lab J. Clin. Invest. Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent
Supplement: 2019-04 Idelevich et al JCI (from our google drive)
3/18/19 Dr. Xu Xiao Tontonoz Lab Cell Metabolism Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling
Supplement: 2019-03 Kim et al Cell Metabolism.pdf (from google drive)
2/25/19 Dr. Huan Wang Reue Lab Cell Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
Supplement: 2019-02 Brandt et al Cell.pdf (from google drive)
1/28/19 Dr. Prashant Rajbhandari Tontonoz Lab Nature Metabolism The long noncoding RNA CHROME regulates cholesterol homeostasis in primates
Supplement: Hennessy et al Nature Met 2019.pdf (from google drive)
11/16/18 Dr. Bethan Clifford Tarling/Vallim Lab Cell Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
10/19/18 Dr. Christina Priest Tontonoz Lab Cell Metabolism Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice
9/21/18 Dr. Michael Shum Liesa Lab Cell Metabolism The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase
8/17/18 Dr. Zhi Zhang Correa Lab Cell Reports A Neural Circuit Underlying the Generation of Hot Flushes
7/20/18 Alex Salisbury Sallam Lab Cell The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets
6/15/18 Dr. Karthickeyan Krishnan Lusis Lab Nature Medicine The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
5/18/18 Joan Cheng Dr. Jenny Link Tarling/Vallim Lab Cell Metabolism Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
4/20/18 Dr. Allison Chi Bensinger Lab Nature Innate and Adaptive Lymphocytes Sequentially Shape the Gut Microbiota and Lipid Metabolism Link
3/16/18 Dr. Alessandra Ferrari Tontonoz Lab Cell Metabolic Induction of Trained Immunity through the Mevalonate Pathway
2/16/18 Karen Ong Reue Lab Cell Metabolism System-wide Benefits of Intermeal Fasting by Autophagy
1/19/18 Lara Bideyan Tontonoz Lab Cell NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis
11/17/17 Elinor Lee Tarling/Vallim Lab Cell Metabolism Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
10/20/17 Dr. Zhengyi Zhang Sallam Lab Cell Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity
9/8/17 Dr. Karthickeyan Krishnan Lusis Lab Cell Metabolism Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis
8/18/17 Kevin Qian Tontonoz Lab Cell Metabolism Long-Term Cold Adaptation Does Not Require FGF21 or UCP1
7/14/17 Dr. Jenny Link Tarling/Vallim Lab Nature Medicine Cold-Induced Conversion of Cholesterol to Bile Acids in Mice Shapes the Gut Microbiome and Promotes Adaptive Thermogenesis
6/23/17 Alex Salisbury Tontonoz Lab Nature Methods Unexpected Mutations After CRISPR–Cas9 Editing in Vivo
5/19/17 Dr. Stephen D. Lee Tontonoz Lab Nature Medicine Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
4/21/2017 Dr. Wayne Hsieh Bensinger Lab PLoS Pathogens DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target
3/17/17 Dr. Jie Gao Tontonoz Lab Nature Neurotoxic Reactive Astrocytes are Induced by Activated Microglia
2/17/17 Dr. Laurent Vergnes Reue Lab Nature Persistent microbiome alterations modulate the rate of post-dieting weight regain
1/20/17 Dr. Marcus Tol Tontonoz Lab Cell Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
11/18/16 Dr. Bo Wang Tontonoz Lab Nature Fatty Acid synthesis configures the plasma membrane for inflammation in diabetes
10/21/16 Dr. Bethan Clifford Tarling/Vallim Lab J. Clin. Invest. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors
9/16/16 Jose L. Orozco Tontonoz Lab J. Biol. Chem Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation
8/19/16 Dr. Li Zhang Tontonoz Lab Nature TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis
6/17/16 Albert Sek Reue Lab Cell The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia
5/20/16 Dr. Xin Rong Tontonoz Lab Cell Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts
4/15/16 Dylan Zhou and Joe Argus Bensinger Lab Dev. Cell Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
3/18/16 Dr. Liz Tarling Tarling/Vallim Lab Science Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
2/19/16 Dr. Prashant Rajbhandari Tontonoz Lab Nature Depletion of fat-resident Treg cells prevents age-associated insulin resistance
1/15/16 Dr. Jihane Benhammou Beaven Lab NEJM FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
11/20/15 Jaspreet Sandhu Tontonoz Lab Cell Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
10/16/15 Dr. Stephen D. Lee Tontonoz Lab Nature The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1